And he's now moved into a new home, though that wasn't as routine as he'd have perhaps hoped.
De Roon was substituted after just 22 minutes of his Middlesbrough debut in Saturday’s 1-1 draw with Stoke City, having damaged his hamstrings as he stretched to win possession.
"But he said 'Middlesbrough is a quiet area, it's relaxed, it's good for your family'.
"I don't think so yet," he laughs.
"That, for me, was really important. I like quiet areas. I don't like being in a really big city with all the hype and everything. This is perfect."
"Before that I was a player who, how can I say it, avoided the duels and the tackling. Then when I broke my leg I thought I have to play a different style of game otherwise this could happen again.
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"I signed here for four years and I hope I will complete that four years and hopefully stay even longer.
"I hope I can play one time. I think when I develop here a little bit more than I already have then if you are a Premier League player and playing every week you will be considered for the national team.
He has discussed the possibility of a loan deal for Everton’s Brendan Galloway, who is also interesting Newcastle United, but the Merseyside club are reluctant to loan the youngster to one of their top-flight rivals.
“I can’t be disappointed with our attitude and performance,” he said. “You can’t forget that three months ago, Stoke finished in ninth position in the Premier League for the third season and we were in the Championship.
“I don’t have to say so much about him because he is also a really big guy here (in England), maybe one of the biggest who ever played in English football.
“It’s important for strikers to score, and especially for Alvaro,” said Karanka. “When we signed him, I said that he needed to recover his confidence. But he’s won the Premier League with Manchester City so he can’t forget how to play.
"It's nice to read about the nicknames but that's not the most important thing," he adds.
The only alternative is inexperienced Belgian youngster Julien de Sart, but having shelled out £12m to sign de Roon from Atalanta, Karanka will not be returning to the transfer market in order to plug a short-term gap.
Julien de Sart and Calum Chambers were quizzed by children in an event supporting the Show Racism The Red Card campaign
"You have to fight for your place. We have four midfielders and when Grant Leadbitter comes back in a month or something like that we will have five. That's really good."
"That was really disappointing but I'm a really optimistic person and the next day I said to the guys here and to my family that I would come back as soon as possible and show them that I'm the player who they took from Atalanta."
“ David Nugent is always looking for a small joke,” de Roon said.
"It was quite difficult because we have 10 new players who all need a new house and everybody wants the same house," he laughs.
With Adam Forshaw and Adam Clayton for company in the centre of midfield and Grant Leadbitter to still return from injury, he also relishes the competition for places.
“I was always a big fan of Steven Gerrard,” de Roon continued.
"I like to go in for the duels. Then, in Italy, I had a good season and the names came."
“It’s been an amazing start, and now he’s got to keep working. He’s scored one, but has to keep working in the same way.”
"That was especially the case in Italy," he says.
He's doing that on Teesside. One of his young children has started school and he stresses the importance of them learning the language.
The Dutchman hobbled off injured, admitting he felt like crying in the two or three hours that followed.
de Roon, Marten - Middlesbrough (ENG)
His commitment to the cause has entrenched de Roon as a fans' favourite at his previous clubs.
"It's a dream for every footballer to play for your country, especially for Holland because it's a really big country.
"We have some really nice places like Yarm and York around. It's good to live here. It's a good atmosphere in the area and the club is like a family.
"Really happy with my transfer!" he tweeted. "Let's make a good season in the Premier League. Come on The Boro!"
"Holland, Italy and England are all good places to live. If, say, a club from Russia came then it's another question. But England is almost the same as Holland so in one minute she said 'of course, if everything goes through you have to do it'."
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It's the intensity of the Premier League which has caught him by surprise but he relishes the challenges ahead, starting against Tottenham on Saturday afternoon.
"Moving and taking my stuff everywhere (can be difficult), especially for the kids.
The effect of his injury is compounded by the continued absence of Leadbitter, who is still around four weeks away from full fitness following hernia surgery earlier this summer.
Middlesbrough said on their official club website the transfer fee paid for De Roon would remain undisclosed.
Having spent just a year in Italy after his move from Heerenveen, de Roon wants to get settled at a club and in an area. For his family's sake as well as his.
It was Negredo’s first Premier League goal since he scored for Manchester City at Newcastle in January 2014, and means he has now scored with his first attempt on target for each of his last two English employers.